NCI's Chemical Biology Consortium

 

Current CBC Projects

Interrogation of Key Genomic Alterations in Glioblastoma Multiforme (GBM) for Identification of Molecular Pathways Critical to GBM Tumorigenesis and Progression

 

Validation of metabolic pathways as potential therapeutic targets in cancer

News

New anti-inflammatory drugs pinch off reactive oxygen species at the source
Cancer Genomics Center, funded by the NCI, targets protein networks for drug discovery
New Class of Potential Drugs Inhibits Inflammation in Brain. --ScienceNews
Chemical Biology Discovery Center hosts workshop on Cell-Based Assays for HTS.
NCI announces Funding the ECBDC for Glioblastoma Multiforme project.
NCI Names Emory to Chemical Biology Consortium

Recent Publications

Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits. Chem Biol. 2012 Jun 22;19(6):752-63.
Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proc Natl Acad Sci USA 2012 Feb 8; Epub Ahead of Press.
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl Acad Sci USA 2011 Sep 9; Epub Ahead of Press.
A Novel High Throughput Screening Assay for Discovery of Molecules that Increase Cellular Tetrahydrobiopterin. Journal of Biomolecular Screening [In Press]
A Dual-Readout F2 Assay That Combines Fluorescence Resonance Energy Transfer and Fluorescence Polarization for Monitoring Bimolecular Interactions. ASSAY and Drug Development Technologies. [Epub ahead of print]
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51. Epub 2010 Dec 29.
Synthesis and Identification of New 4-Arylidene Curcumin Analogues as Potential Anticancer Agents Targeting Nuclear Factor-κB Signaling Pathway. J Med Chem. 2010 Nov 11. [Epub ahead of print]