Raymond Dingledine, Ph.D.   Professor and Chairman                   Emory University School of Medicine         5001 Rollins Research Center         1510 Clifton Road         Atlanta, GA 30322-3090         Tel: 404-727-5983         Tel: 404-727-5635 (Lab)         Fax: 404-727-0365         rdingledine@pharm.emory.edu                   Ph.D., Stanford University, 1975         Postdoctoral Fellow, University of Cambridge, England, 1975-77           Postdoctoral Fellow, University of Oslo, Norway, 1977-78           Research Associate, Duke University, 1978           Assistant, Associate, full Professor, University of North Carolina at Chapel Hill, 1978-92           Visiting Scientist, The Salk Institute, 1990-91           Emory University, 1992       Research Interest:                   Glutamate receptors mediate the vast majority of excitatory synaptic transmission in the brain. A major research effort in my lab is focused on regulation of glutamate receptor-mediated synaptic transmission in the brain by the co-activation of selected G-protein coupled receptors. A second research emphasis involves the use of microarray and associated technologies to identify novel targets and pathways involved in the basic cellular and molecular mechanisms of epilepsy. These research interests converge and have highlighted a role for cyclooxygenase-2 (COX2) signaling pathways in the cognitive deficits, impaired synaptic inhibition, and neurodegeneration caused by seizures. We are currently seeking the prostaglandin receptors responsible for each of these effects; we will then employ a chemical biology approach to develop novel small molecule modulators of these receptors in an effort to interrupt the development of epilepsy. As a whole our work integrates information from a variety of experimental strategies to contribute to a better understanding of epilepsy, with broad implications for other brain disorders including stroke and schizophrenia.               Publications