About Us

The Hepler lab is located at the Emory University School of Medicine within the Department of Pharmacology. We study how brain cells communicate with one another to modulate synaptic signaling and brain physiology. 

More specifically, our research focuses on identifying key brain signaling proteins (RGS proteins, G proteins, receptors and linked signaling proteins) and understanding how these proteins work together to propagate neurotransmitter and neuromodulator signals to regulate neuronal and glial functions. 

These cellular functions are critical for learning and memory as well as tissue regeneration following brain injury (e.g., stroke).  Impairment of these processes contributes to cognitive decline associated with neurodegenerative diseases (e.g., Alzheimer 's disease and others) and aging. To study these mechanisms, we employ a variety of modern, multidisciplinary, experimental approaches including cellular signaling and imaging, molecular biology techniques, recombinant and native protein biochemistry, proteomics, and mouse behavioral models. 

Please use the top navigation menu to learn more about our lab.


John R. Hepler, PhD
Emory University School of Medicine
O. Wayne Rollins Research Center
1510 Clifton Road,
Room G205
Atlanta, GA 30322

Office phone: 404-727-3641
Lab phone: 404-727-8192
Email: jhepler@emory.edu

Hepler Lab Group