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Edward Morgan
Professor

Emory University School of Medicine
Department of Pharmacology
5119 Rollins Research Center
1510 Clifton Road
Atlanta, GA 30322-3090


Phone : 404-727-5986
Fax     : 404-727-0365
Lab     : 404-727-0364

Email:  etmorga@emory.edu
Research Area:
Regulation of drug metabolizing enzymes; cytochrome P-450; inflammation; biological effects of nitric oxide
Research Interests:
Our laboratory aims to advance fundamental understanding of the regulation of cytochrome P450 enzymes, in order to provide the basis for rational design of drug doses and regimens in disease states and to identify P450 enzymes as novel therapeutic targets in infectious or inflammatory disease. We use live and sterile models of infection to study the differential regulation of hepatic cytochrome P450s in response to inflammation. Current research is focused on the down-regulation and induction of expression of the central enzymes of drug metabolism, the cytochromes P450 in a rodent model of enteropathogenic e.coli infection and a model of inflammatory bowel disease. We also study both the transcriptional and posttranscriptional mechanisms of regulation of P450 by inflammatory responses, with a current focus on the understudied area of regulated P450 protein degradation. In particular, we are elucidating the mechanisms by which endogenous nitric oxide in hepatocytes targets particular P450 enzymes for regulated degradation.
Education:
Ph.D., University of Glasgow, 1979
Postdoctoral Fellow, University of Michigan, 1979-82
Visiting Scientist, Karolinska Institute, Stockholm, Sweden, 1982-86      
Emory University, 1986

Appointments:
Assistant Professor, Emory University School of Medicine, 1986-1992
Associate Professor, Emory University School of Medicine, 1992-1999
Professor, Emory University School of Medicine, 1999

DEPARTMENT FOCUS

Image courtesy of the Feng Lab

Image courtesy of the Feng Lab

Mouse dentate hilus region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Image courtesy of the Hepler Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

Image courtesy of the Traynelis Lab

Hippocampal CA3 4 days after status epilepticus. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse dentate granule cell region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Hippocampal CA1 4 days after status epilepticus in COX2 cKO. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

20 June 2014
Researchers from Ohio State, Emory receive grants from Harrington Discovery Institute and Alzheimer's Drug Discovery...
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25 March 2014
It's All In Your Head
Renowned pharmacologist
Dr Raymond Dingledine shares his insight into the field,...
02 December 2014
No Seminar
09 December 2014
Shiva Gangappa, DVM, PhD, Influenza Division, NCIRD & Adjunct Faculty,...
"Evaluation of Adjunct Therapies in Influenza-Induced Disease Severity"...
16 December 2014
No Seminar
23 December 2014
No Seminar due to the Holiday's
30 December 2014
No Seminar due to the Holiday's
For questions regarding this website, please contact Olga Rivera at orivera@pharm.emory.edu