Emory University School of Medicine
Department of Pharmacology
5119 Rollins Research Center
1510 Clifton Road
Atlanta, GA 30322-3090
Phone : 404-727-5986
Fax : 404-727-0365
Lab : 404-727-0364
Email: etmorga@emory.edu
Regulation of drug metabolizing enzymes; cytochrome P-450; inflammation; biological effects of nitric oxide
Our laboratory aims to advance fundamental understanding of the regulation of cytochrome P450 enzymes, in order to provide the basis for rational design of drug doses and regimens in disease states and to identify P450 enzymes as novel therapeutic targets in infectious or inflammatory disease. We use live and sterile models of infection to study the differential regulation of hepatic cytochrome P450s in response to inflammation. Current research is focused on the down-regulation and induction of expression of the central enzymes of drug metabolism, the cytochromes P450 in a rodent model of enteropathogenic e.coli infection and a model of inflammatory bowel disease. We also study both the transcriptional and posttranscriptional mechanisms of regulation of P450 by inflammatory responses, with a current focus on the understudied area of regulated P450 protein degradation. In particular, we are elucidating the mechanisms by which endogenous nitric oxide in hepatocytes targets particular P450 enzymes for regulated degradation.
Ph.D., University of Glasgow, 1979
Postdoctoral Fellow, University of Michigan, 1979-82
Visiting Scientist, Karolinska Institute, Stockholm, Sweden, 1982-86
Emory University, 1986
Appointments:
Assistant Professor, Emory University School of Medicine, 1986-1992
Associate Professor, Emory University School of Medicine, 1992-1999
Professor, Emory University School of Medicine, 1999
DEPARTMENT FOCUS
Image courtesy of the Feng Lab
Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.
Image courtesy of the Pavlath Lab
Hippocampal CA1 4 days after status epilepticus in COX2 cKO. blue - cell nuclei; green - astrocytes; red - microglia. Courtesy of Dingledine lab.
Image courtesy of the Hepler Lab
Mouse dentate granule cell region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.
Image courtesy of the Traynelis Lab
Mouse dentate hilus region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.
Image courtesy of the Feng Lab
Hippocampal CA3 4 days after status epilepticus. blue - cell nuclei; green - astrocytes; red - microglia. Courtesy of Dingledine lab.
Image courtesy of the Feng Lab
Image courtesy of the Pavlath Lab
Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.
Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.
Woodruff Health Sciences Center | Feb. 11,...