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Edward Morgan
Professor

Emory University School of Medicine
Department of Pharmacology
5119 Rollins Research Center
1510 Clifton Road
Atlanta, GA 30322-3090


Phone : 404-727-5986
Fax     : 404-727-0365
Lab     : 404-727-0364

Email:  etmorga@emory.edu
Research Area:
Regulation of drug metabolizing enzymes; cytochrome P-450; inflammation; biological effects of nitric oxide
Research Interests:
Our laboratory aims to advance fundamental understanding of the regulation of cytochrome P450 enzymes, in order to provide the basis for rational design of drug doses and regimens in disease states and to identify P450 enzymes as novel therapeutic targets in infectious or inflammatory disease. We use live and sterile models of infection to study the differential regulation of hepatic cytochrome P450s in response to inflammation. Current research is focused on the down-regulation and induction of expression of the central enzymes of drug metabolism, the cytochromes P450 in a rodent model of enteropathogenic e.coli infection and a model of inflammatory bowel disease. We also study both the transcriptional and posttranscriptional mechanisms of regulation of P450 by inflammatory responses, with a current focus on the understudied area of regulated P450 protein degradation. In particular, we are elucidating the mechanisms by which endogenous nitric oxide in hepatocytes targets particular P450 enzymes for regulated degradation.
Education:
Ph.D., University of Glasgow, 1979
Postdoctoral Fellow, University of Michigan, 1979-82
Visiting Scientist, Karolinska Institute, Stockholm, Sweden, 1982-86      
Emory University, 1986

Appointments:
Assistant Professor, Emory University School of Medicine, 1986-1992
Associate Professor, Emory University School of Medicine, 1992-1999
Professor, Emory University School of Medicine, 1999

DEPARTMENT FOCUS

Image courtesy of the Traynelis Lab

Mouse dentate granule cell region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Image courtesy of the Hepler Lab

Image courtesy of the Pavlath Lab

Hippocampal CA3 4 days after status epilepticus. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Image courtesy of the Feng Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Hippocampal CA1 4 days after status epilepticus in COX2 cKO. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

Mouse dentate hilus region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

11 January 2016
Dedication of the Winship Partner in Research Endowed Chair

Sent on behalf of Walter J. Curran, Jr., MD, Executive...
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01 March 2015
Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side...
06 September 2016
TBA
13 September 2016
TBA
20 September 2016
Shannon Gourley, PhD, Assistant Professor, Dept. of Pediatrics &...
"How Events During Adolescence Shape the Brain and Behavior: ...
27 September 2016
Richard Neubig, M.D., PhD., Chair & Professor, Dept. of Pharmacology &...
"Role of G-alpha-o (GNAO1) in Human Epilepsy and Movement Disorders"
04 October 2016
TBA
11 October 2016
Thomas Kukar, PhD, Assistant Professor, Dept. of Pharmacology, Emory...
TBA
18 October 2016
TBA
25 October 2016
Qiang Zhang, PhD, Associate Professor, Dept. of Computational...
TBA
01 November 2016
TBA
08 November 2016
Nidhi Sahni, PhD, Assistant Professor, Laboratory of Cancer Systems...
TBA
15 November 2016
Society for Neuroscience
November 12th - 16th, San Diego
22 November 2016
TBA
29 November 2016
TBA
06 December 2016
Rory A. Fisher, PhD, Professor, Dept. of Pharmacology, University of...
TBA
13 December 2016
Zaneta Nikolovska-Coleska, PhD, Associate Professor, Dept. of...
TBA
13 December 2016
TBA
20 December 2016
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NO SEMINAR
Closed due to the...
27 December 2016
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NO SEMINAR
Closed - due to the...
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