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Renee Read
Assistant Professor


Emory University School of Medicine
Department of Pharmacology
1510 Clifton Road, Suite 5017 / Lab 5068
Rollins Research Center
Atlanta, GA 30322-


Phone : 404-727-5985
Fax     : 404-727-0365
Lab     : 404-727-7132

Email: renee.read@emory.edu
Research Area:
Cellular and molecular mechanisms underlying glioblastoma and glial development
Research Interests:
Our lab seeks to understand the molecular logic underlying the initiation and progression of primary brain tumors in order to gain new insights into neurodevelopment and neurophysiology that can contribute to improved treatment and diagnosis of these diseases. Glioblastomas, the most common and deadly primary brain tumors, display signature genetic lesions that perturb the activity of genes that normally regulate essential developmental and homeostatic processes in the central nervous system. In particular, the most common mutations found in glioblastomas result in constitutive activation of receptor tyrosine kinase (RTK) and Pi-3 kinase (PI3K) signaling pathways. Yet, how these mutations drive tumorigenesis is unclear, and how to effectively target these pathways therapeutically remains to be determined. Our research program is designed to discover new regulators of gliomagenesis using multidisciplinary genetic and molecular approaches.

To investigate RTK and PI3K dependent gliomagenesis, we created a Drosophila glioblastoma model in which constitutive co-activation of RTK and PI3K pathways gives rise to malignant, neoplastic glial tumors with many pathogenic features of human glioblastoma. To find new genes that govern glial tumorigenesis, we performed genetic screens using this Drosophila model, from which we isolated several novel kinases that are required for neoplastic glial proliferation. Human orthologs of these novel kinases have been assessed for involvement in glioblastoma using bioinformatics, neuropathology, and functional analysis in human tumors and mammalian glioblastoma model systems. Our results reveal that several novel kinases are subject to genetic mutation and/or altered expression in human tumors. Ongoing studies of these kinases are aimed at elucidating their roles in tumorigenesis and normal brain development in both Drosophila and mammalian systems. Our research also demonstrates that particular types of glial progenitor cells are prone to neoplastic transformation. Ongoing studies of glial cells are aimed at characterizing signals that drive their tumorigenic transformation and at identifying biomarkers that define these cell types.



Education:
Ph.D., Washington University, 2003

Ph.D., Developmental Biology, Washington University, 2003
Postdoctoral Fellow, The Salk Institute for Biological Studies, 2004-2008
Senior Postdoctoral Fellow, The Salk Institute for Biological Studies and the University of California San Diego, 2008-2011
Assistant Professor, Emory University, 2011-present


DEPARTMENT FOCUS

Image courtesy of the Feng Lab

Hippocampal CA3 4 days after status epilepticus. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Hippocampal CA1 4 days after status epilepticus in COX2 cKO. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

Mouse dentate granule cell region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

Mouse dentate hilus region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Image courtesy of the Traynelis Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Hepler Lab

20 June 2014
Researchers from Ohio State, Emory receive grants from Harrington Discovery Institute and Alzheimer's Drug Discovery...
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25 March 2014
It's All In Your Head
Renowned pharmacologist
Dr Raymond Dingledine shares his insight into the field,...
21 November 2014
Masatoshi Hagiwara, M.D., Ph.D., Professor & Vice Dean of Graduate...
"Challenges to Cure...
25 November 2014
No Seminar due to the Thanksgiving Holiday
02 December 2014
No Seminar
09 December 2014
Shiva Gangappa, DVM, PhD, Influenza Division, NCIRD & Adjunct Faculty,...
"Evaluation of Adjunct Therapies in Influenza-Induced Disease Severity"...
16 December 2014
No Seminar
23 December 2014
No Seminar due to the Holiday's
30 December 2014
No Seminar due to the Holiday's
For questions regarding this website, please contact Olga Rivera at orivera@pharm.emory.edu