Edward Morgan, Ph.D.
   Professor  
   
     
      Emory University School of Medicine  
      5119 Rollins Research Center  
      1510 Clifton Road  
      Atlanta, GA 30322-3090  
      Tel: 404-727-5986  
      Tel: 404-727-0364 (Lab)  
      Fax: 404-727-0365  
      etmorga@emory.edu  
         
      Postdoctoral Fellow, University of Michigan, 1979-82  
      Visiting Scientist, Karolinska Institute, Stockholm, Sweden, 1982-86  
        Emory University, 1986  
    Research Interest:      
   
     
 
Our laboratory aims to advance fundamental understanding of the regulation of cytochrome P450 enzymes, in order to provide the basis for rational design of drug doses and regimens in disease states and to identify P450 enzymes as novel therapeutic targets in infectious or inflammatory disease. We use live and sterile models of infection to study the differential regulation of hepatic cytochrome P450s in response to inflammation. Current research is focused on the down-regulation and induction of expression of the central enzymes of drug metabolism, the cytochromes P450 in a rodent model of enteropathogenic e.coli infection and a model of inflammatory bowel disease. We also study both the transcriptional and posttranscriptional mechanisms of regulation of P450 by inflammatory responses, with a current focus on the understudied area of regulated P450 protein degradation. In particular, we are elucidating the mechanisms by which endogenous nitric oxide in hepatocytes targets particular P450 enzymes for regulated degradation.  
   
     
       
   
     
   
Laboratory Personnel:
     
   
Choon-myung Lee, Ph.D.
      
   
Malik Raynor