Postsynaptic Glutamate Receptor Function and Modulation

We study all aspects of postsynaptic glutamate receptors, including both structural and functional properties of AMPA, kainate, and NMDA receptors.  Kinetic and structural models are used to evaluate synaptic function and allosteric regulation by extracellular and intracellular substances, as well as phosphorylation.   Understanding glutamate receptors will provide a clearer understanding of synaptic transmission and plasticity, as well as provide potentially novel therapeutic strategies.

Serine Protease Receptor Function in the CNS

Serine protease receptors (PAR-1,2,3,4) are highly expressed in the central nervous system. However, their function is still unknown. We are examining their potential for sculpting excitatory synaptic transmission and influencing synaptic plasticity. In addition, these receptors become overactivated during blood brain barrier breakdown when blood-derived serine proteases enter brain tissue. This extravasation of serine proteases contributes to neuronal damage, and may represent a novel therapeutic target.

Neuroprotection

A large number of processes are involved in neuronal injury by stroke, head trauma, infection, hypoxia, or ischemia. We are evaluating the relative contribution of a range of events that occur during brain injury, including excitotoxicity due to overactivation of glutamate receptors, breakdown of the blood brain barrier, and inflammation.

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Traynelis Lab | 5062 Rollins Research Center | 1510 Clifton Road | Atlanta, GA 30322
Phone: 404-727-1375     Fax: 404-727-0365
Updated 04/22/2009