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Postsynaptic Glutamate Receptor Function and Modulation We study all aspects of
postsynaptic glutamate receptors, including both structural and
functional properties of AMPA, kainate, and NMDA receptors.
Kinetic and structural models are used to evaluate synaptic function
and allosteric regulation by extracellular and intracellular
substances, as well as phosphorylation. Understanding glutamate
receptors will provide a clearer understanding of synaptic transmission
and plasticity, as well as provide potentially novel therapeutic
strategies. |
Serine protease receptors (PAR-1,2,3,4) are
highly expressed in the central nervous system. However, their function
is still unknown. We are examining their potential for sculpting
excitatory synaptic transmission and influencing synaptic plasticity.
In addition, these receptors become overactivated during blood brain
barrier breakdown when blood-derived serine proteases enter brain
tissue. This extravasation of serine proteases contributes to neuronal
damage, and may represent a novel therapeutic target. |
A large number of processes are involved in neuronal injury by stroke, head trauma, infection, hypoxia, or ischemia. We are evaluating the relative contribution of a range of events that occur during brain injury, including excitotoxicity due to overactivation of glutamate receptors, breakdown of the blood brain barrier, and inflammation. |
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(L-to-R) Phuong Le, Katie Vance, Praseeda Mullasseril, Stephen Traynelis, Kimberly Haustein, Kasper Hansen, Hongjie Yuan, Natalie Kurtkaya, Anna Orr. |
Recently Published: Zinc inhibition of rat
NR1/NR2A |
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Traynelis Lab | People
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