Murphy Lab
Department of Pharmacology
IndexFind HelpFind SitesFind JobsFind PeopleFind Events
Research
Reprints
Methods
People
Home
Recent Publications
  • Nickenig, G. and T.J. Murphy.  Enhanced AT1 receptor mRNA degradation and induction of polyribosomal mRNA binding proteins by angiotensin II in vascular smooth muscle cells, Mol Pharmacol, 50:743-751 (1996).
  • Boss, V., Joshi-Talpade, D. and T.J. Murphy.  Induction of NFAT-mediated transcription by Gaq-protein coupled receptors in lymphoid and non-lymphoid cells, J. Biological Chem. 271:10429-10432 (1996).
  • Wang, X.-F., Nickenig, G. and T.J. Murphy.  The vascular smooth muscle cell angiotensin II AT1-receptor mRNA is destabilized by cAMP elevating agents, Mol Pharmacol, 52:781-787 (1997).
  • Chung,D.S., Traynelis, S.F., Murphy, T.J. and P.J. Conn.  4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis, J. Pharmacol. Exp. Ther; 283:742-749 (1997).
  • Boss, V., Abbott, K.L., Wang, X.F., Pavlath, G.K. and T.J. Murphy. The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface receptors., J. Biological Chem. 273:19664-19671 (1998).
  • Boss, V., Wang, X., Koppelman, L., Xu. K., and T.J. Murphy.  Histamine induces NFAT-mediated transcription and cyclosporin A-sensitive IL-8 mRNA expression in human umbilical endothelial cells, Mol Pharmacol. 54: 264-272, (1998).
  • Wang, X. and T.J. Murphy.  Inhibition of cAMP-dependent kinase by expression of a protein kinase inhibitor/enhanced green fluorescent fusion protein attenuates angiotensin II-induced type I AT1 receptor mRNA down regulation in vascular smooth muscle cells. Mol Pharmacol, 54:514-524 (1998).
  • Abbott, K.L., Friday, B.B., Thaloor, D., Murphy, T.J. and G.K. Pavlath.  Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells, Mol Biol Cell, 9:2905-2916 (1998).
  • Adams, B.K, Obertone, T.S., Wang, X.  and T.J. Murphy. Relationship between internalization and mRNA decay in down regulation of recombinant angiotensin AT1 receptor expression in smooth muscle cells. Mol Pharmacol, 55:1028-1036 (1999).
  • Abbott, K.L., Loss, J.R., Robida, A.M. and T.J. Murphy.  Evidence that Gaq-coupled receptor induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells. Mol Pharmacol, 58:946-953 (2000).
  • Abbott KL, Robida AM, Davis ME, Pavlath GK, Camden JM, Turner JT, Murphy TJ. Differential regulation of vascular smooth muscle nuclear factor-kappaB by Gaq-coupled and cytokine receptors. J. Mol Cell Cardiol, 32:391-403 (2000).
  • Robida, A.M., Xu, K., Ellington, M.L. and T.J. Murphy.  Cyclosporin A selectively inhibits mitogen induced cyclooxygenase-2 gene transcription in vascular smooth muscle cells. Mol Pharmacol, 58:701-708 (2000).
  • Xu, K. and T.J. Murphy. Reconstitution of angiotensin receptor mRNA down regulation in vascular smooth muscle: Post-transcriptional control by protein kinase A but not mitogenic signalling directed by the 5’-untranslated region, J. Biological Chem 275:7604-7611 (2000).
  • Zhong, H., Murphy, T.J., and K.P. Minneman.  Activation of STAT’s by alpha1A-adrenergic receptor stimulation in PC12 cells. Mol Pharmacol, 57:961-967 (2000).
  • Minneman, K.P., Lee, D., Zhong, H., Berts, A., Abbott, K.L. and T.J. Murphy. Transcriptional responses to growth factor and G protein coupled receptors in PC12 cells: comparison of a1-adrenergic receptor subtypes. J. Neurochem, 74:2392-2400 (2000).
  • Schaffhauser, H., Cai, Z., Hubalek, F., Macek, T.A., Pohl, J., Murphy, T.J. and P.J. Conn.  cAMP-Dependent protein kinase inhibits mGLuR2 coupling to G-proteins by direct receptor phosphorylation. J Neuroscience 20:5663-5670 (2000).
  • Xu, K., Robida, A.M and T.J. Murphy.  Immediate early MEK1 dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Gaq-coupled receptor signaling, J. Biological Chem 275:23012-23019 (2000).
  • Wang, X. and T.J. Murphy. The inducible cAMP-early repressor ICERIIg inhibits CREB and AP-1 transcription  but not AT1 receptor gene expression in vascular smooth muscle cells.  Mol Cell Biochem 212:111-119 (2000).

Return to TJMLab Homepage
email: medtjm@emory.edu
Find Events Find People Find Jobs Find Sites Find Help Index
BACK TO TOP