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Rita Nahta
Assistant Professor


Emory University School of Medicine
Department of Pharmacology
Winship Cancer Institute, Room C4008      
1365-C Clifton Road      
Atlanta, GA 30322


Phone : 404-778-3097
Fax     : 404-727-0365
Lab     : 404-778-3064

Email:  rnahta@emory.edu
Research Area:
Biological and therapeutic implications of growth factor signaling crosstalk in breast cancer
Research Interests:
Our laboratory focuses on the biological and therapeutic implications of growth factor signaling crosstalk in breast cancer. Significant advances in the treatment of metastatic breast cancer include the development of therapies targeted against specific cancer-causing molecules. However, the success of these mono-targeted therapies is often limited by cross-talk between multiple signaling pathways. One molecule that is overexpressed in about 25% of metastatic breast cancers is the HER2/erbB2 oncogene. Approved treatments for HER2-overexpressing breast cancer include the HER2-targeted antibody trastuzumab and the dual EGFR/HER2 kinase inhibitor lapatinib. While both drugs successfully treat a percentage of HER2-overexpressing metastatic breast cancers, a significant number of patients show primary or acquired resistance to these treatments. My laboratory is interested in understanding how cross-talk between HER2 and other growth factor signaling pathways affects the biology of HER2-overexpressing breast cancers, including how signaling cross-talk promotes resistance to trastuzumab and lapatinib. By understanding the basic signaling mechanisms contributing to therapeutic resistance, we can identify new molecular targets against which future drugs can be developed.
Education:
Ph.D., Duke University, 2000      
Postdoctoral Fellow, Harvard Medical School, 2000-2002      
Postdoctoral Fellow, M.D. Anderson Cancer Center, 2002-2004      
Instructor, M.D. Anderson Cancer Center, 2004-2007      
Assistant Professor, Emory University, 2007-present

DEPARTMENT FOCUS

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

Image courtesy of the Traynelis Lab

Image courtesy of the Pavlath Lab

Mouse dentate granule cell region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse dentate hilus region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Hepler Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Image courtesy of the Feng Lab

Hippocampal CA1 4 days after status epilepticus in COX2 cKO. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Hippocampal CA3 4 days after status epilepticus. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

20 June 2014
Researchers from Ohio State, Emory receive grants from Harrington Discovery Institute and Alzheimer's Drug Discovery...
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Tin Tin Su, PhD, Professor, Dept. of Moelcular, Cellular &...
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No Seminar due to Society for Neuroscience 2014
November 15th - 19th, Washington D. C.
25 November 2014
No Seminar due to the Thanksgiving Holiday
02 December 2014
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09 December 2014
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16 December 2014
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23 December 2014
No Seminar due to the Holiday's
30 December 2014
No Seminar due to the Holiday's
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