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Rita Nahta
Assistant Professor


Emory University School of Medicine
Department of Pharmacology
Winship Cancer Institute, Room C4008      
1365-C Clifton Road      
Atlanta, GA 30322


Phone : 404-778-3097
Fax     : 404-727-0365
Lab     : 404-778-3064

Email:  rnahta@emory.edu
Research Area:
Biological and therapeutic implications of growth factor signaling crosstalk in breast cancer
Research Interests:
Our laboratory focuses on the biological and therapeutic implications of growth factor signaling crosstalk in breast cancer. Significant advances in the treatment of metastatic breast cancer include the development of therapies targeted against specific cancer-causing molecules. However, the success of these mono-targeted therapies is often limited by cross-talk between multiple signaling pathways. One molecule that is overexpressed in about 25% of metastatic breast cancers is the HER2/erbB2 oncogene. Approved treatments for HER2-overexpressing breast cancer include the HER2-targeted antibody trastuzumab and the dual EGFR/HER2 kinase inhibitor lapatinib. While both drugs successfully treat a percentage of HER2-overexpressing metastatic breast cancers, a significant number of patients show primary or acquired resistance to these treatments. My laboratory is interested in understanding how cross-talk between HER2 and other growth factor signaling pathways affects the biology of HER2-overexpressing breast cancers, including how signaling cross-talk promotes resistance to trastuzumab and lapatinib. By understanding the basic signaling mechanisms contributing to therapeutic resistance, we can identify new molecular targets against which future drugs can be developed.
Education:
Ph.D., Duke University, 2000      
Postdoctoral Fellow, Harvard Medical School, 2000-2002      
Postdoctoral Fellow, M.D. Anderson Cancer Center, 2002-2004      
Instructor, M.D. Anderson Cancer Center, 2004-2007      
Assistant Professor, Emory University, 2007-present

DEPARTMENT FOCUS

Image courtesy of the Pavlath Lab

Hippocampal CA3 4 days after status epilepticus. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Pavlath Lab

Image courtesy of the Feng Lab

Mouse dentate hilus region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Image courtesy of the Hepler Lab

Mouse dentate granule cell region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Image courtesy of the Feng Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

Hippocampal CA1 4 days after status epilepticus in COX2 cKO. blue - cell nuclei; green -  astrocytes; red - microglia. Courtesy of Dingledine lab.

Image courtesy of the Traynelis Lab

Mouse hippocampal CA1 region 4 days after status epilepticus. Blue = cell nuclei; green = astrocytes; red = microglia. Courtesy of Dingledine lab.

25 March 2014
It's All In Your Head
Renowned pharmacologist
Dr Raymond Dingledine shares his insight into the field,...
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24 February 2014
Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic...
22 April 2014
J. Steven Leeder, PharmD, PhD, Marion Merrell Dow / Missouri Endowed,...
"Ontogeny of Drug Disposition, and Implications for Pharmacogenomics in...
29 April 2014
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ASPET:  Experimental Biology...
06 May 2014
Alfred H. Merrill, GA Tech
"A Sphingolipid Primer for Pharmacologists: What they are, from whence...
13 May 2014
No Seminar
20 May 2014
Rita Nahta, Assistant Professor, Dept. of Pharmacology, Emory...
"Compensatory Signaling Facilitates Escape from HER2-Targeted...
For questions regarding this website, please contact Olga Rivera at orivera@pharm.emory.edu